Endocrine Abstracts

The reproductive system is controlled by (GnRH) secretion from the brain, which is finely modulated by a number of factors, including gonadal sex steroids and inhibins. It was recently claimed that kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion. Therefore, we have developed highly specific and sensitive fluoro-immunoassays (FIAs) using Eu-labeled antigens for KP 10 and GnIH. In this study, the distributions of KP 10 and GnIH...

Background: Aldosterone to renin ratio (ARR) is the gold standard for screening of primary aldosteronism (PA). However, the lower value of ARR cannot rule out the possibility of PA. In this study, we evaluated the change of plasma aldosterone concentration (PAC) in ACTH stimulation among hypertensive patients and explored whether it improved the sensitivity of ARR for detecting PA.Method: Eighty-five patients with hypertension with plasma renin activity ...